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1、6 Deregulation of Cell Cycle Leads to Cancer Dali Salvador The Persistence of Memory,1931 Museum of Modern Art(MoMA),New York Absence of Checkpoint Leads to Chromosomal ReAbsence of Checkpoint Leads to Chromosomal Re-ReplicationReplication Wild type Rad17-/-缺失檢驗點導致染色體重復制 Leads to Chromosomal Breakag

2、eLeads to Chromosomal Breakage ATR-/-缺失檢驗點導致染色體斷裂 Cyclin D1 Is Amplified in Cancerous CellsCyclin D1 Is Amplified in Cancerous Cells FISH(Fluorescence in situ hybridization 原位熒光雜交原位熒光雜交)Experiments 癌細胞中cyclin D1擴增 Chromosomal Abnormality Is a Hallmark of CancerChromosomal Abnormality Is a Hallmark of Cancer Wild type Human breast cancer cell SKY(Spectral karyotype)Experiments 染色體異常是癌癥的特異標志 Nature Review Cancer 2009 9:153-167 Summary Video